EMILIN2 Elastin microfibril interface located protein, potential modifier of thrombosisReport as inadecuate




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Thrombosis Journal

, 9:9

First Online: 11 May 2011Received: 09 March 2010Accepted: 11 May 2011

Abstract

BackgroundElastin microfibril interface located protein 2 EMILIN2 is an extracellular glycoprotein associated with cardiovascular development. While other EMILIN proteins are reported to play a role in elastogenesis and coagulation, little is known about EMILIN2 function in the cardiovascular system. The objective of this study was to determine whether EMILIN2 could play a role in thrombosis.

ResultsEMILIN2 mRNA was expressed in 8 wk old C57BL-6J mice in lung, heart, aorta and bone marrow, with the highest expression in bone marrow. In mouse cells, EMILIN2 mRNA expression in macrophages was higher than expression in endothelial cells and fibroblasts. EMILIN2 was identified with cells and extracellular matrix by immunohistochemistry in the carotid and aorta. After carotid ferric chloride injury, EMILIN2 was abundantly expressed in the thrombus and inhibition of EMILIN2 increased platelet de-aggregation after ADP-stimulated platelet aggregation.

ConclusionsThese results suggest EMILIN2 could play a role in thrombosis as a constituent of the vessel wall and-or a component of the thrombus.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-9560-9-9 contains supplementary material, which is available to authorized users.

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Author: Qila Sa - Jane L Hoover-Plow

Source: https://link.springer.com/article/10.1186/1477-9560-9-9







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