Increased serum myeloid-related protein 8-14 level is associated with atherosclerosis in type 2 diabetic patientsReport as inadecuate

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Cardiovascular Diabetology

, 10:41

First Online: 18 May 2011Received: 18 January 2011Accepted: 18 May 2011


BackgroundMyeloid-related protein 8-14 MRP8-14 is a stable heterodimer formed by two different calcium-binding proteins MRP8 and MRP14. Studies have identified that MRP8-14 regulates vascular inflammation and serves as a novel marker of acute coronary syndrome. In this study, we evaluated the correlation between serum levels of MRP8-14, hsCRP, endogenous secretory receptor for advanced glycation end-products esRAGE and the occurrence of coronary artery disease CAD, or carotid intima-media thickness IMT when CAD was not yet developed in diabetic patients.

MethodsSerum levels of MRP8-14, esRAGE and hsCRP were measured in 375 diabetic patients. Then the results of those who had CAD were compared against who had not. Also, we investigated the associations between above-mentioned indicators and IMT of subjects without CAD in both diabetic group and non-diabetic one.

ResultsSerum MRP8-14 was significantly higher in CAD than in non-CAD group 9.7 ± 3.6 ug-ml vs. 8.2 ± 3.0 ug-ml, P < 0.001. It was associated with severity of CAD r = 0.16, P = 0.026. In non-CAD group, MRP8-14 was associated with IMT in patients with r = 0.30, P < 0.001 or without diabetes r = 0.26, P = 0.015. The areas under the curves of receiver operating characteristic for CAD were 0.63 95% CI 0.57-0.68 for MRP8-14, 0.76 95% CI 0.71-0.81 for hsCRP and 0.62 95% CI 0.56 -0.67 for esRAGE.

ConclusionIn summary, we report that diabetic patients with CAD had elevated plasma MRP8-14 levels which were also positively correlated with the severity of CAD and carotid IMT in patients without clinically overt CAD.

KeywordsMRP8-14 Diabetes mellitus Coronary artery disease Intima media thickness AbbreviationsBUNblood urea nitrogen

CADcoronary artery disease

CIconfidence interval

CrClcreatinine clearance

DMdiabetes mellitus

esRAGEendogenous secretory receptor for advanced glycation endproducts

HbA1cglycosylated hemoglobin A1c

hsCRPhigh sensitivity C reactive protein

IMTintima-media thickness

MRP8-14myeloid-related protein 8-14

QCAquantitative coronary analyses

SDstandard deviation

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-41 contains supplementary material, which is available to authorized users.

Wei Xia Jian contributed equally to this work.

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Author: Wen Hui Peng - Wei Xia Jian - Hai Ling Li - Lei Hou - Yi Dong Wei - Wei Ming Li - Ya Wei Xu


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