Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly menReport as inadecuate




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Cardiovascular Diabetology

, 10:44

First Online: 23 May 2011Received: 29 March 2011Accepted: 23 May 2011

Abstract

BackgroundAdipocyte fatty acid-binding protein A-FABP has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease CAD.

MethodsTwo hundred eleven consecutive male patients mean age: 66 years, range: 33-87 years were enrolled from inpatients who underwent coronary angiography. Age-matched male subjects n = 211 having no evidence of CAD served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays.

ResultsPlasma A-FABP levels in CAD patients were significantly higher than in control subjects median IQR, 20.6 15.7-27.8 ng-mL vs. 15.1 11.7-19.9 ng-mL, p < 0.01. Multivariate logistic regression analysis revealed that an increased plasma A-FABP level was independently associated with the presence of CAD in all subjects adjusted odds ratio: 1.76, 95% confidence interval: 1.14 to 2.70, p = 0.01. Furthermore, sub-analysis based on age showed that this association remained significant in subjects aged < 65 years adjusted odds ratio: 3.06, 95% confidence interval: 1.34 to 6.98, p < 0.01, but not in subjects aged ≥65 years.

ConclusionsIncreased plasma A-FABP in non-elderly men had a significant association with the presence of CAD, independent of established CAD risk factors.

Keywordsadipocyte fatty acid-binding protein coronary artery disease risk factor Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-44 contains supplementary material, which is available to authorized users.

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Author: Masayuki Doi - Toru Miyoshi - Satoshi Hirohata - Kazufumi Nakamura - Shinichi Usui - Ko Takeda - Mutsumi Iwamoto - Shozo K

Source: https://link.springer.com/article/10.1186/1475-2840-10-44







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