Role of Hepatic Lipase and Endothelial Lipase in High-Density Lipoprotein—Mediated Reverse Cholesterol TransportReport as inadecuate




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Current Atherosclerosis Reports

, Volume 13, Issue 3, pp 257–265

First Online: 22 March 2011

Abstract

Reverse cholesterol transport RCT constitutes a key part of the atheroprotective properties of high-density lipoproteins HDL. Hepatic lipase HL and endothelial lipase EL are negative regulators of plasma HDL cholesterol levels. Although overexpression of EL decreases overall macrophage-to-feces RCT, knockout of both HL and EL leaves RCT essentially unaffected. With respect to important individual steps of RCT, current data on the role of EL and HL in cholesterol efflux are not conclusive. Both enzymes increase hepatic selective cholesterol uptake; however, this does not translate into altered biliary cholesterol secretion, which is regarded the final step of RCT. Also, the impact of HL and EL on atherosclerosis is not clear cut; rather it depends on respective experimental conditions and chosen models. More mechanistic insights into the diverse biological properties of these enzymes are therefore required to firmly establish EL and HL as targets for the treatment of atherosclerotic cardiovascular disease.

KeywordsAtherosclerosis Bile Cardiovascular disease Cholesterol Efflux Endothelial lipase Feces Hepatic lipase High density lipoproteins Inflammation Liver Macrophage Macrophage-to-feces Phospholipase Reverse cholesterol transport Risk Therapy Triglycerides  Download fulltext PDF



Author: Wijtske Annema - Uwe J. F. Tietge

Source: https://link.springer.com/article/10.1007/s11883-011-0175-2







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