Bradykinin type 2 receptor -9-9 genotype is associated with triceps brachii muscle hypertrophy following strength training in young healthy menReport as inadecuate

Bradykinin type 2 receptor -9-9 genotype is associated with triceps brachii muscle hypertrophy following strength training in young healthy men - Download this document for free, or read online. Document in PDF available to download.

BMC Musculoskeletal Disorders

, 13:217

Rehabilitation, physical therapy and occupational health


BackgroundBradykinin type 2 receptor B2BRK genotype was reported to be associated with changes in the left-ventricular mass as a response to aerobic training, as well as in the regulation of the skeletal muscle performance in both athletes and non-athletes. However, there are no reports on the effect of B2BRK 9-bp polymorphism on the response of the skeletal muscle to strength training, and our aim was to determine the relationship between the B2BRK SNP and triceps brachii functional and morphological adaptation to programmed physical activity in young adults.

MethodsIn this 6-week pretest-posttest exercise intervention study, twenty nine healthy young men 21.5 ± 2.7 y, BMI 24.2 ± 3.5 kg-m were put on a 6-week exercise protocol using an isoacceleration dynamometer 5 times a week, 5 daily sets with 10 maximal elbow extensions, 1 minute rest between sets. Triceps brachii muscle volumes were assessed by using magnetic resonance imaging before and after the strength training. Bradykinin type 2 receptor 9 base pair polymorphism was determined for all participants.

ResultsFollowing the elbow extensors training, an average increase in the volume of both triceps brachii was 5.4 ± 3.4% from 929.5 ± 146.8 cm pre-training to 977.6 ± 140.9 cm after training, p<0.001. Triceps brachii volume increase was significantly larger in individuals homozygous for −9 allele compared to individuals with one or two +9 alleles −9-9, 8.5 ± 3.8%; vs. -9-+9 and +9-+9 combined, 4.7 ± 4.5%, p < 0.05. Mean increases in endurance strength in response to training were 48.4 ± 20.2%, but the increases were not dependent on B2BRK genotype −9-9, 50.2 ± 19.2%; vs. -9-+9 and +9-+9 combined, 46.8 ± 20.7%, p > 0.05.

ConclusionsWe found that muscle morphological response to targeted training – hypertrophy – is related to polymorphisms of B2BRK. However, no significant influence of different B2BRK genotypes on functional muscle properties after strength training in young healthy non athletes was found. This finding could be relevant, not only in predicting individual muscle adaptation capacity to training or sarcopenia related to aging and inactivity, but also in determining new therapeutic strategies targeting genetic control of muscle function, especially for neuromuscular disorders that are characterized by progressive adverse changes in muscle quality, mass, strength and force production e.g., muscular dystrophy, multiple sclerosis, Parkinson’s disease.

KeywordsBradykinin Muscle hypertrophy Strength training AbbreviationsACEAngiotensin converting enzyme

B2BRKBradykinin type 2 receptor

mRNAMessenger RNA

BMBody mass

BHBody height

BMIBody mass index

MSMaximal strength

ESEndurance muscle strength

FRFatigue rate

TRRepetition time

TEEcho time

FOVField of view

ROIRegion of interest

CSACross-sectional area

VmMuscle volume

1RM1-repetition maximum

AVEAverage value

SDStandard deviation.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-13-217 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Author: Jelena Z Popadic Gacesa - Milica Momcilovic - Igor Veselinovic - David A Brodie - Nikola G Grujic


Related documents