Insulin-Like Growth Factor-1 IGF-1 Reduces ischemic changes and increases circulating angiogenic factors in experimentally - induced myocardial infarction in ratsReport as inadecuate




Insulin-Like Growth Factor-1 IGF-1 Reduces ischemic changes and increases circulating angiogenic factors in experimentally - induced myocardial infarction in rats - Download this document for free, or read online. Document in PDF available to download.

Vascular Cell

, 3:13

First Online: 09 June 2011Received: 14 January 2011Accepted: 09 June 2011

Abstract

BackgroundCoronary artery disease is a global health concern in the present day with limited therapies. Extensive efforts have been devoted to find molecular therapies to enhance perfusion and function of the ischemic myocardium. Aim of the present study was to look into the effects of insulin like growth factor -1 IGF-1 on circulating angiogenic factors after myocardial ischemia in rats.

MethodsAdult male Sprague-Dawley rats were randomly divided into 10-days control, myocardial infarction, IGF-1 alone 2 μg-rat-day and ISO+IGF-1 groups. Isoproterenol ISO, a synthetic catecholamine was used to induce myocardial infarction. Serum transforming growth factor-β TGF-β and vascular endothelial growth factor VEGF levels were checked after 10-days of IGF-1 administration.

ResultsThere was a significant increase in heart weight after IGF-1 treatment. A significant increase in cardiac enzyme level CK-MB and LDH was seen in isoproterenol treated rats when compared to control group. IGF-1treatment induced a significant increase in serum angiogenic factors, IGF-1, VEGF and TGF beta levels. IGF-1 also reduced the ischemic changes in the myocardium when compared to the isoproterenol alone treated group.

ConclusionsIn conclusion, treatment with insulin-like growth factor-1 IGF-1 in myocardial infarction significantly increased circulating angiogenic growth factors like IGF-1, VEGF and TGF beta thus, protecting against myocardial ischemia.

Electronic supplementary materialThe online version of this article doi:10.1186-2045-824X-3-13 contains supplementary material, which is available to authorized users.

Mathews Lisa, Nagaraja Haleagrahara and Srikumar Chakravarthi contributed equally to this work.

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Author: Mathews Lisa - Nagaraja Haleagrahara - Srikumar Chakravarthi

Source: https://link.springer.com/article/10.1186/2045-824X-3-13







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