Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki diseaseReport as inadecuate




Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease - Download this document for free, or read online. Document in PDF available to download.

Arthritis Research and Therapy

, 14:R251

First Online: 21 November 2012Received: 12 July 2012Revised: 07 November 2012Accepted: 20 November 2012

Abstract

IntroductionKawasaki disease KD, an acute febrile disease, characterized by systemic vasculitis, predominantly affects infants and children under 5 years of age. Coronary artery lesions CALs are its most critical complication, and the etiology remains unknown yet. In order to explore the value of resistin, S100A12 and soluble receptor for advanced glycation end products sRAGE in the pathophysiology of KD, we studied the serum levels of resistin, S100A12 and sRAGE in different stages of KD.

MethodsSerum levels of resistin, S100A12 and sRAGE were measured by enzyme-linked immunosorbent assay ELISA method in 15 healthy children and 40 KD patients at acute, afebrile and subacute stage.

ResultsThe resistin and S100A12 levels, including the ratio of resistin to sRAGE and S100A12 to sRAGE increased significantly in the acute stage, and decreased progressively in the afebrile and subacute stage. However, the sRAGE levels decreased significantly in the acute stage, and increased progressively in the afebrile and subacute stage. In the acute, afebrile and subacute stage, the resistin levels were higher in intravenous immunoglobulin IVIG non-responders 0.64 ± 0.30, 0.48 ± 0.35, 0.28 ± 0.19, × 10 ng-ml than in IVIG responders 0.35 ± 0.24, 0.21 ± 0.19, 0.12 ± 0.05, × 10 ng-ml. In the acute and subacute stage, the S100A12 levels were higher in IVIG non-responders 7.92 ± 2.61, 4.98 ± 4.75, × 10 ng-ml than in IVIG responders 5.05 ± 3.22, 2.35 ± 2.26, × 10 ng-ml. In the afebrile and subacute stage, the sRAGE levels were lower in IVIG non-responders 3.51 ± 2.64, 3.65 ± 3.27, × 10 pg-ml than in IVIG responders 6.00 ± 2.78, 7.19 ± 2.88, × 10 pg-ml. The resistin levels were positively correlated with S100A12 levels. The sRAGE levels were negatively related with S100A12 and resistin levels.

ConclusionsResistin, S100A12 and sRAGE are involved in the pathophysiology of KD.

AbbreviationsANOVAanalysis of variance

CADcoronary artery disease

CALcoronary artery lesion

CRPC-reactive protein

CVDcardiovascular disease

ELISAenzyme-linked immunosorbent assay

ENRAGEextracellular newly identified RAGE-binding protein

ESRerythrocyte sedimentation rate

KDKawasaki disease

IVIGintravenous immunoglobulin

LSDleast significant difference

RAGEreceptor for advanced glycation end products

sRAGEsoluble receptor for advanced glycation end products

WBCwhite blood cell.

Electronic supplementary materialThe online version of this article doi:10.1186-ar4094 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Yanqi Qi - Fangqi Gong - Qing Zhang - Chunhong Xie - Wei Wang - Songling Fu

Source: https://link.springer.com/







Related documents