Coadministration of tacrolimus with corticosteroid accelerates recovery in refractory patients with polymyositis- dermatomyositis: a retrospective studyReport as inadecuate




Coadministration of tacrolimus with corticosteroid accelerates recovery in refractory patients with polymyositis- dermatomyositis: a retrospective study - Download this document for free, or read online. Document in PDF available to download.

BMC Musculoskeletal Disorders

, 13:228

First Online: 22 November 2012Received: 18 March 2012Accepted: 19 November 2012

Abstract

BackgroundTo investigate whether or not coadministration of tacrolimus TAC with prednisolone PSL can produce a beneficial effect in the treatment of polymyositis- dermatomyositis PM-DM.

MethodsWe reviewed medical records of 32 PM-DM patients who had been admitted to our hospital, and abstracted those who had received TAC in addition to oral PSL for treatment. The clinical usefulness of TAC in PM-DM was objectively evaluated focusing upon the manual muscle strength test MMT score, serum creatine kinase CK and tapering of PSL.

ResultsNine patients with PM and 6 with DM were enrolled in this study. TAC was added because of difficulty in reduction of PSL in 12 patients and recurrence with corticosteroid-induced complications in the remaining 3. Both PM and DM patients showed significant increases in the MMT score and significant decreases in serum CK 1 to 3 months after starting TAC compared with before. Skin symptoms in a clinically amyopathic DM patient also improved 1 month after starting TAC. The daily dosage of PSL could be significantly reduced in both PM and DM after starting TAC compared with before. No serious adverse events ascribable to TAC occurred in any patients.

ConclusionAdditional use of TAC with PSL may safely promote improvement of PM-DM and also accelerate tapering of the latter.

KeywordsDermatomyositis Polymyositis Tacrolimus Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-13-228 contains supplementary material, which is available to authorized users.

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Author: Yasuhiro Shimojima - Wataru Ishii - Masayuki Matsuda - Ko-ichi Tazawa - Shu-ichi Ikeda

Source: https://link.springer.com/







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