Comprehensive assessment of spotty calcifications on computed tomography angiography: Comparison to plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysisReport as inadecuate




Comprehensive assessment of spotty calcifications on computed tomography angiography: Comparison to plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysis - Download this document for free, or read online. Document in PDF available to download.

Journal of Nuclear Cardiology

, 18:893

First Online: 19 July 2011Received: 18 March 2011Accepted: 28 June 2011

Abstract

BackgroundThe purpose of the study was to systematically compare calcification patterns in plaques on computed tomography angiography CTA with plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysis IVUS-VH.

Methods and ResultsIn total, 108 patients underwent CTA and IVUS-VH. On CTA, calcification patterns in plaques were classified as non-calcified, spotty or dense calcifications. Plaques with spotty calcifications were differentiated into small spotty <1 mm, intermediate spotty 1-3 mm and large spotty calcifications ≥3 mm. Plaque characteristics deemed more high-risk on IVUS-VH were defined by % necrotic core NC and presence of thin cap fibroatheroma TCFA. Overall, 300 plaques were identified both on CTA and IVUS-VH. % NC core was significantly higher in plaques with small spotty calcifications as compared to non-calcified plaques 20% vs 13%, P = .006. In addition, there was a trend for a higher % NC in plaques with small spotty calcifications than in plaques with intermediate spotty calcifications 20% vs 14%, P = .053. Plaques with small spotty calcifications had the highest % TCFA as compared to large spotty and dense calcifications 31% vs 9% and 31% vs 6%, P < .05.

ConclusionPlaques with small spotty calcifications on CTA were related to plaque characteristics deemed more high-risk on IVUS-VH. Therefore, CTA may be valuable in the assessment of the vulnerable plaque.

Key WordsAtherosclerosis computed tomography CT vulnerable atherosclerotic plaque Funding: Dr van Velzen is supported by the Dutch Heart Foundation The Hague, The Netherlands, Grant nr. 2007B223. Dr de Graaf is co-supported by the Dutch Technology Foundation STW Utrecht, The Netherlands, applied science division of I and the Technology Program of the Ministry of Economic Affairs, Grant nr. 10084.

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Author: Joëlla E. van Velzen - Fleur R. de Graaf - Michiel A. de Graaf - Joanne D. Schuijf - Lucia J. Kroft - Albert de Ro

Source: https://link.springer.com/







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