YKL-40 levels are independently associated with albuminuria in type 2 diabetesReport as inadecuate




YKL-40 levels are independently associated with albuminuria in type 2 diabetes - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:54

First Online: 22 June 2011Received: 19 May 2011Accepted: 22 June 2011

Abstract

Objective and designYKL-40 is involved in inflammation and endothelial dysfunction, and is increased in patients with type 1 diabetes, with an independent association between increasing YKL-40 levels and increasing levels of albuminuria. YKL-40 is associated with atherosclerosis and an increased cardiovascular mortality in the general population. In the present study YKL-40 levels were examined in patients with type 2 diabetes T2D with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease.

Materials and methodsOne-hundred-five patients with T2D were examined: 49 with normoalbuminuria N, U-albumin-creatinine < 2.5 mg-mmol, 35 with persistent microalbuminuria MA, 2.5-25 mg-mmol and 21 with persistent macroalbuminuria-diabetic nephropathy DN, > 25 mg-mmol. The control group consisted of 20 healthy individuals C. Groups were matched according to age, gender and known duration of diabetes.

ResultsMedian levels interquartile range of serum YKL-40 were significantly higher in N and MA vs. C 86 55-137 ng-ml and 84 71-147 ng-ml, respectively vs. 41 33-55 ng-ml, p < 0.01 and even higher in patients with DN 120 83-220 ng-ml, p < 0.001 for all comparisons. YKL-40 levels correlated with urinary albumin-creatinine-ratio in the total group of participants r = 0.41, p < 0.001. Significant intercorrelations of YKL-40 were found with age, duration of diabetes, systolic blood pressure, lipid levels, HbA1c and HOMA-IR. After adjustment for significant covariates, albuminuria was significantly associated with YKL-40 levels r = 0.32, p = 0.006.

ConclusionsYKL-40 levels are elevated in patients with T2D with an independent association between increasing YKL-40 levels and increasing levels of albuminuria. The study suggests a role of YKL-40 in the progressing vascular complications in patients with T2D.

KeywordsType 2 diabetes biomarker nephropathy Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-54 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Anne K Røndbjerg - Emina Omerovic - Henrik Vestergaard

Source: https://link.springer.com/article/10.1186/1475-2840-10-54







Related documents