Reflections on the theory of silver bullet octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysisReport as inadecuate




Reflections on the theory of silver bullet octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis - Download this document for free, or read online. Document in PDF available to download.

EJNMMI Research

, 1:9

First Online: 26 July 2011Received: 10 May 2011Accepted: 26 July 2011

Abstract

The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on this review. The central issue of this paper will be the use of somatostatin analogs, i.e., octreotide, in clinical imaging procedures as well as in relation to neuroendocirne tumors. Newly described characteristics of G-protein coupled receptors such as the formation of receptor mosaics will be discussed. A small section will enumerate the regulatory processes found in the cell membrane. Possible new interpretations, other than tumor detection, based on imaging procedures with somatostatin analogs will be presented. The readers will be taken to situations such as inflammation, nociception, mechanosensing, chemosensing, fibrosis, taste, and vascularity where somatostatin is involved. Thyroid-associated orbitopathy will be used as a model for the development of multi-agent therapeutics. The final graphical summary depicts the multifactorial properties of ligand binding.

KeywordsMichaelis-Menten ligand receptor GPCR somatostatin octreotide homodimers heterodimers receptor mosaics multifractal analysis morphogens morphostats Abbreviations68Ga-TOCGa-DOTA-Tyr octreotide

7TMseven7 -transmembrane helical receptors

CNScentral nervous system

GIgastrointestinal

GPCRG-protein coupled receptors

MRImagnetic resonance imaging

NETneuroendocrine tumors

RAMPSreceptor-activity-modifying proteins

Seselenium

SSAsomatostatin analogs

SSTsomatostatin

SSTRsomatostatin receptors

TAOthyroid- associated orbitopathy

TCMtraditional Chinese medicine

TMDtransmembrane domains.

Electronic supplementary materialThe online version of this article doi:10.1186-2191-219X-1-9 contains supplementary material, which is available to authorized users.

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Author: Roy Moncayo

Source: https://link.springer.com/







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