Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional studyReport as inadecuate

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Cardiovascular Diabetology

, 10:55

First Online: 23 June 2011Received: 12 May 2011Accepted: 23 June 2011


BackgroundType 2 diabetes is associated with increased levels of Angiopoietin-2 Ang-2 and soluble Tie-2 sTie-2, but its impact on vascular disease is still unknown. This study aimed to further explore the associations of Ang-2 and sTie-2 with metabolic control and diabetic complications.

MethodsIn a cross-sectional designed study, levels of Ang-2 and sTie-2 as well as their relationships to cardiometabolic parameters were determined in 80 type 2 diabetic subjects age 65 ± 7 years, female 47.4%.

ResultsAfter controlling for age and BMI, Ang-2 levels were associated with levels of sTie-2, diastolic blood pressure, plasma insulin, homeostasis model assessment of insulin resistance HOMA-IR, creatinine, glomerular filtration rate GFR, and gamma-glutamyl transferase GGT all p < 0.02. Presence of diabetic macrovascular complications, polyneuropathy and insulin therapy were associated with higher Ang-2 levels p < 0.05. Conversely, sTie-2 levels were associated with glycated hemoglobin HbA1c, fasting plasma glucose and insulin, HOMA-IR, triglyceride, and liver function parameters all p < 0.03. Multiple linear regression analysis showed that Ang-2 remained significantly associated only with levels of GGT p < 0.04, whereas sTie-2 remained significantly associated with HbA1c , insulin levels, and HOMA-IR p < 0.03. No differences in Ang-2 and sTie-2 levels were observed with regard to gender of participants.

ConclusionsAng-2 is independently associated with levels of GGT while sTie-2 is independently associated with levels of HbA1c , plasma insulin and HOMA-IR in type 2 diabetic subjects. Therefore we suggest that the associations of Ang-2 and sTie-2 with type 2 diabetes are based on different patho-physiological mechanisms.

List of abbreviationsAGEAdvanced glycation end product


ALTAlanin aminotransferase

ASTAsparate aminotransferase

BMIBody mass index

GFRGlomerular filtration rate

GGTGama glutamyl-transferase

HbA1c Glycated hemoglobin

HOMA-IRHomeostasis model assessment of insulin resistance

ROSReactive oxygen species

sTie-2Soluble Tie-2

Tie-2Endothelium specific receptor tyrosine kinase

VEGFVascular endothelial growth factor.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-55 contains supplementary material, which is available to authorized users.

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Author: Sazan Rasul - Marie Helene Reiter - Aysegul Ilhan - Katharina Lampichler - Ludwig Wagner - Alexandra Kautzky-Willer


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