Intersection of Inflammation and Herbal Medicine in the Treatment of OsteoarthritisReport as inadecuate

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Current Rheumatology Reports

, Volume 14, Issue 6, pp 604–616

First Online: 18 September 2012


Herbal remedies and dietary supplements have become an important area of research and clinical practice in orthopaedics and rheumatology. Understanding the risks and benefits of using herbal medicines in the treatment of arthritis, rheumatic diseases, and musculoskeletal complaints is a key priority of physicians and their patients. This review discusses the latest advances in the use of herbal medicines for treating osteoarthritis OA by focusing on the most significant trends and developments. This paper sets the scene by providing a brief introduction to ethnopharmacology, Ayurvedic medicine, and nutrigenomics before discussing the scientific and mechanistic rationale for targeting inflammatory signalling pathways in OA by use of herbal medicines. Special attention is drawn to the conceptual and practical difficulties associated with translating data from in-vitro experiments to in-vivo studies. Issues relating to the low bioavailability of active ingredients in herbal medicines are discussed, as also is the need for large-scale, randomized clinical trials.

KeywordsOsteoarthritis Rheumatic diseases Musculoskeletal complaints Inflammation Herbal medicine Ethnopharmacology Ayurvedic medicine Nutrigenomics Clinical trials Articular cartilage Synovium Mesenchymal stem cell Phytochemicals Flavonoids Catechins Treatment  Download fulltext PDF

Author: Ali Mobasheri


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