Day-to-Day Test–Retest Variability of CBF, CMRO2, and OEF Measurements Using Dynamic 15O PET StudiesReport as inadecuate




Day-to-Day Test–Retest Variability of CBF, CMRO2, and OEF Measurements Using Dynamic 15O PET Studies - Download this document for free, or read online. Document in PDF available to download.

Molecular Imaging and Biology

, Volume 13, Issue 4, pp 759–768

First Online: 11 August 2010

Abstract

PurposeWe assessed test–retest variability of cerebral blood flow CBF, cerebral blood volume CBV, cerebral metabolic rate of oxygen CMRO2, and oxygen extraction fraction OEF measurements derived from dynamic O positron emission tomography PET scans.

ProceduresIn seven healthy volunteers, complete test–retest O PET studies were obtained; test–retest variability and left-to-right ratios of CBF, CBV, OEF, and CMRO2 in arterial flow territories were calculated.

ResultsWhole-brain test–retest coefficients of variation for CBF, CBV, CMRO2, and OEF were 8.8%, 13.8%, 5.3%, and 9.3%, respectively. Test–retest variability of CBV left-to-right ratios was <7.4% across all territories. Corresponding values for CBF, CMRO2, and OEF were better, i.e., <4.5%, <4.0%, and <1.4%, respectively.

ConclusionsThe test–retest variability of CMRO2 measurements derived from dynamic O PET scans is comparable to within-session test–retest variability derived from steady-state O PET scans. Excellent regional test–retest variability was observed for CBF, CMRO2, and OEF. Variability of absolute CBF and OEF measurements is probably affected by physiological day-to-day variability of CBF.

Key wordsParametric CBF CMRO2 OEF PET Significance: The present study provides reference data for absolute and relative i.e., left-to-right ratios CBF, CBV, CMRO2, and OEF values derived from dynamic O PET scans. In addition, the observed very good test–retest variability of CBF, CMRO2, and OEF validates the use of a dynamic scanning procedure for O PET studies.

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Author: Jochem P. Bremmer - Bart N. M. van Berckel - Suzanne Persoon - L. Jaap Kappelle - Adriaan A. Lammertsma - Reina Kloet

Source: https://link.springer.com/







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