Feasibility of subendocardial and subepicardial myocardial perfusion measurements in healthy normals with 15O-labeled water and positron emission tomographyReport as inadecuate




Feasibility of subendocardial and subepicardial myocardial perfusion measurements in healthy normals with 15O-labeled water and positron emission tomography - Download this document for free, or read online. Document in PDF available to download.

Journal of Nuclear Cardiology

, Volume 18, Issue 4, pp 650–656

First Online: 26 April 2011Received: 04 February 2011Accepted: 02 April 2011

Abstract

BackgroundPositron emission tomography PET enables robust and reproducible measurements of myocardial blood flow MBF. However, the relatively limited resolution of PET till recently prohibited distinction between the subendocardial and the subepicardial layers in non-hypertrophied myocardium. Recent developments in hard- and software, however, have enabled to identify a transmural gradient difference in animal experiments. The aim of this study is to determine the feasibility of subendocardial and subepicardial MBF in normal human hearts assessed with O-labeled water PET.

MethodsTwenty-seven healthy subjects mean age 41 ± 13 years; 11 men were studied with O-labeled water PET to quantify resting and hyperaemic adenosine MBF at a subendocardial and subepicardial level. In addition, cardiac magnetic resonance imaging was performed to determine left ventricular LV volumes and function.

ResultsMean rest MBF was 1.46 ± 0.49 in the subendocardium, and 1.14 ± 0.342 mL · min · g in the subepicardium P < .001. MBF during vasodilation was augmented to a greater extent at the subepicardial level subendocardium vs subepicardium: 3.88 ± 0.86 vs 4.14 ± 0.88 mL · min · g, P = .013. The endocardial-to-epicardial MBF ratio decreased significantly during hyperaemia 1.35 ± 0.23 to 1.12 ± 0.20, P < .001. Hyperaemic transmural MBF was inversely correlated with left ventricular end-diastolic volume index LVEDVI r = 0.41, P = .0003, with greater impact however at the subendocardial level.

ConclusionsO-labeled water PET enables MBF measurements with distinction of the subendocardial and subepicardial layers in the normal human heart and correlates with LVEDVI. This PET technique may prove useful in evaluating patients with signs of ischaemia due to coronary artery disease or microvascular dysfunction.

KeywordsPositron emission tomography imaging coronary microcirculation myocardial blood flow subendocardial See related editorial, doi:10.1007-s12350-011-9381-0.

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Author: Ilse A. Vermeltfoort - Pieter G. Raijmakers - Mark Lubberink - Tjeerd Germans - Albert C. van Rossum - Adriaan A. Lamme

Source: https://link.springer.com/







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