Antidiabetic pharmacotherapy and anamnestic hypoglycemia in a large cohort of type 2 diabetic patients - an analysis of the DiaRegis registryReport as inadecuate




Antidiabetic pharmacotherapy and anamnestic hypoglycemia in a large cohort of type 2 diabetic patients - an analysis of the DiaRegis registry - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:66

First Online: 14 July 2011Received: 02 June 2011Accepted: 14 July 2011

Abstract

BackgroundWe aimed to identify predictors of anamnestic hypoglycaemia in type-2 diabetic patients on oral mono- or dual oral combination antidiabetic pharmacotherapy.

MethodsDiaRegis is a prospective registry in type-2 diabetic patients in primary care. Odds ratios OR with 95% confidence intervals were determined from univariate logistic regression. Using multivariate logistic regression analysis with stepwise backward selection at an alpha of 0.05 independent predictors of hypoglycaemia were determined.

Results3,808 patients had data on hypoglycaemia available median age 65.9 years, 46.6% female. 10.8% had at least one anamnestic hypoglycaemic episode within the previous 12 months. Patients with hypoglycaemia received more sulfonylureas OR 2.16; 95%CI 1.75-2.67 and less metformin OR 0.64; 95%CI 0.50-0.82. On top of metformin, patients with thiazolidine OR 0.50; 95%CI 0.28-0.89 and DPP-4 inhibitor use OR 0.34; 95%CI 0.16-0.70 had a decreased risk for hypoglycaemia while it was again increased with sulfonylureas OR 2.08; 95%CI 1.44-2.99. Age < 65 years was an independent predictor of a reduced hypoglycaemia incidence OR 0.76; 95%CI 0.59-0.96, low HbA1c OR 1.68; 95%CI 1.31-2.14, stroke-TIA OR 1.72; 95%CI 1.08-2.72, heart failure OR 1.77; 95%CI 1.28-2.45, and the use of sulfonylureas OR 2.58; 95%CI 2.03-3.29 were independent predictors of increased risk.

ConclusionsThe results indicate that the risk of hypoglycaemia might be substantially reduced by carefully selecting antidiabetic pharmacotherapy in patients with type-2 diabets in primary care.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-66 contains supplementary material, which is available to authorized users.

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Author: Diethelm Tschöpe - Peter Bramlage - Christiane Binz - Michael Krekler - Tanja Plate - Evelin Deeg - Anselm K Gitt

Source: https://link.springer.com/article/10.1186/1475-2840-10-66







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