Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgeryReport as inadecuate




Impaired fasting glucose is associated with increased perioperative cardiovascular event rates in patients undergoing major non-cardiothoracic surgery - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:63

First Online: 14 July 2011Received: 06 May 2011Accepted: 14 July 2011

Abstract

BackgroundDiabetes mellitus DM is a well-established risk factor for perioperative cardiovascular morbidity and mortality in patients undergoing noncardiac surgery. However, the impact of preoperative glucose levels on perioperative cardiovascular outcomes in patients undergoing nonemergent, major noncardiothoracic surgery is unclear.

Methods and ResultsA total of 680 patients undergoing noncardiothoracic surgery were prospectively evaluated. Patients older than 18 years who underwent an elective, nonday case, open surgical procedure were enrolled. Electrocardiography and cardiac biomarkers were obtained 1 day before surgery, and on days 1, 3 and 7 after surgery. Preoperative risk factors and laboratory test results were measured and evaluated for their association with the occurrence of in-hospital perioperative cardiovascular events. Impaired fasting glucose IFG defined as fasting plasma glucose values of 100 to 125 mg-dl; DM was defined as fasting plasma glucose ≥ 126 mg-dl and-or plasma glucose ≥ 200 mg-dl or the current use of blood glucose-lowering medication, and glucose values below 100 mg-dl were considered normal. Plasma glucose levels were significantly higher in patients with perioperative cardiovascular events n = 80, 11.8% in comparison to those without cardiovascular events 131 ± 42.5 vs 106.5 ± 37.5, p < 0.0001. Multivariate analysis revealed that patients with IFG and DM were at 2.1- and 6.4-fold increased risk of perioperative cardiovascular events, respectively. Every 10 mg-dl increase in preoperative plasma glucose levels was related to a 11% increase for adverse perioperative cardiovascular events.

ConclusionsNot only DM but also IFG is associated with increased perioperative cardiovascular event rates in patients undergoing noncardiothoracic surgery.

Keywordsnoncardiothoracic surgery preoperative glucose levels cardiovascular complications Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-63 contains supplementary material, which is available to authorized users.

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Author: Murat Biteker - Akin Dayan - Mehmet M Can - Erkan İlhan - Funda S Biteker - Ahmet Tekkeşin - Dursun Duman

Source: https://link.springer.com/article/10.1186/1475-2840-10-63







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