Association of plasma osteoprotegerin and adiponectin with arterial function, cardiac function and metabolism in asymptomatic type 2 diabetic menReport as inadecuate




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Cardiovascular Diabetology

, 10:67

First Online: 19 July 2011Received: 11 April 2011Accepted: 19 July 2011

Abstract

BackgroundOsteoprotegerin OPG, a soluble member of the tumor necrosis factor receptor superfamily, is linked to cardiovascular disease. Negative associations exist between circulating OPG and cardiac function. The adipocytokine adiponectin ADPN is downregulated in type 2 diabetes mellitus T2DM and coronary artery disease and shows an inverse correlation with insulin sensitivity and cardiovascular disease risk. We assessed the relationship of plasma OPG and ADPN and arterial function, cardiac function and myocardial glucose metabolism in T2DM.

MethodsWe included 78 asymptomatic men with uncomplicated, well-controlled T2DM, without inducible ischemia, assessed by dobutamine-stress echocardiography, and 14 age-matched controls. Cardiac function was measured by magnetic resonance imaging, myocardial glucose metabolism MMRglu by 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography. OPG and ADPN levels were measured in plasma.

ResultsT2DM patients vs. controls showed lower aortic distensibility, left ventricular LV volumes, impaired LV diastolic function and MMRglu all P < 0.05. In T2DM men vs. controls, OPG levels were higher P = 0.02, whereas ADPN concentrations were decreased P = 0.04. OPG correlated inversely with aortic distensibility, LV volumes and E-A ratio diastolic function, and positively with LV mass-volume ratio all P < 0.05. Regression analyses showed the associations with aortic distensibility and LV mass-volume ratio to be independent of age-, blood pressure- and glycated hemoglobin HbA1c. However, the associations with LV volumes and E-A ratio were dependent of these parameters. ADPN correlated positively with MMRglu P < 0.05, which, in multiple regression analysis, was dependent of whole-body insulin sensitivity, HbA1c and waist.

ConclusionsOPG was inversely associated with aortic distensibility, LV volumes and LV diastolic function, while ADPN was positively associated with MMRglu. These findings indicate that in asymptomatic men with uncomplicated T2DM, OPG and ADPN may be markers of underlying mechanisms linking the diabetic state to cardiac abnormalities.

Trial registrationCurrent Controlled Trials ISRCTN53177482

Keywordsosteoprotegerin adiponectin type 2 diabetes mellitus arterial function cardiac function myocardial metabolism List of abbreviationsT2DMtype 2 diabetes mellitus

LVleft ventricular

TNFtumor necrosis factor

RANKLreceptor activator of nuclear factor-κB ligand

ADPNadiponectin

NT-pro-BNPN-terminal-pro-B-type natriuretic peptide

HDLhigh density lipoprotein

HbA1cglycated hemoglobin

M-valuewhole-body insulin sensitivity

BMIbody mass index

MRImagnetic resonance imaging

E-Aratio of peak filling rates of the early filling phase and arterial contraction

E deceleration peakpeak deceleration gradient of the early filling phase

E-Eaestimated LV filling pressures

PETPositron Emission Tomography

MMRglumyocardial metabolic rate of glucose.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-67 contains supplementary material, which is available to authorized users.

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Author: Weena JY Chen - Luuk J Rijzewijk - Rutger W van der Meer - Martijn W Heymans - Eelco van Duinkerken - Mark Lubberink - A

Source: https://link.springer.com/article/10.1186/1475-2840-10-67







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