Unrequested information from routine diagnostic chest CT predicts future cardiovascular eventsReport as inadecuate

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European Radiology

, Volume 21, Issue 8, pp 1577–1585

First Online: 21 May 2011Received: 24 August 2010Revised: 22 November 2010Accepted: 23 December 2010


ObjectivesAn increase in the number of CT investigations will likely result in a an increase in unrequested information. Clinical relevance of these findings is unknown. This is the first follow-up study to investigate the prognostic relevance of subclinical coronary CAC and aortic calcification TAC as contained in routine diagnostic chest CT in a clinical care population.

MethodsThe follow-up of 10,410 subjects >40 years from a multicentre, clinical care-based cohort of patients included 240 fatal to 275 non-fatal cardiovascular disease CVD events mean follow-up 17.8 months. Patients with a history of CVD were excluded. Coronary 0–12 and aortic calcification 0–8 were semi-quantitatively scored. We used Cox proportional-hazard models to compute hazard ratios to predict CVD events.

ResultsCAC and TAC were significantly and independently predictive of CVD events. Compared with subjects with no calcium, the adjusted risk of a CVD event was 3.7 times higher 95% CI, 2.7–5.2 among patients with severe coronary calcification CAC score ≥6 and 2.7 times higher 95% CI, 2.0–3.7 among patients with severe aortic calcification TAC score ≥5.

ConclusionsSubclinical vascular calcification on CT is a strong predictor of incident CVD events in a routine clinical care population.

KeywordsCoronary artery calcification Computed tomography Cardiovascular disease Stroke Prevention  Download fulltext PDF

Author: Peter C. Jacobs - Martijn J. Gondrie - Willem P. Mali - Ayke L. Oen - Mathias Prokop - Diederick E. Grobbee - Yolanda 

Source: https://link.springer.com/

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