Onset of polyarticular juvenile idiopathic arthritis with both anti-cyclic citrullinated peptide antibodies and rheumatoid factor in a 3-year-old girlReport as inadecuate




Onset of polyarticular juvenile idiopathic arthritis with both anti-cyclic citrullinated peptide antibodies and rheumatoid factor in a 3-year-old girl - Download this document for free, or read online. Document in PDF available to download.

Pediatric Rheumatology

, 10:41

First Online: 13 December 2012Received: 23 May 2012Accepted: 10 December 2012

Abstract

This report describes 3 year old girl with the unusual presentation of polyarticular juvenile idiopathic arthritis JIA with anti-cyclic citrullinated peptide anti-CCP antibodies and a positive rheumatoid factor RF. She was initially treated with a nonsteroidal anti-inflammatory drug NSAID; ibuprofen followed by methotrexate MTX, 10 mg-m-week and prednisolone 0.25 mg-kg-day, but these treatments were ineffective. Administration of tocilizumab, a humanized antihuman interleukin-6 receptor monoclonal antibody, promptly improved her clinical manifestations, and she has been in complete remission DAS28 <2.6 without bone erosion and-or destruction. Positivity for both antibodies anti-CCP and RF can forecast the severity of JIA radiographic bone destruction. In such cases the administration of biologic remissive therapy may be prudent early in the disease course.

KeywordsAnti-CCP antibody Rheumatoid factor JIA Tocilizumab AbbreviationsJIAJuvenile idiopathic arthritis

CCPCyclic citrullinated peptide

RARheumatoid arthritis.

Electronic supplementary materialThe online version of this article doi:10.1186-1546-0096-10-41 contains supplementary material, which is available to authorized users.

Kozo Yasui, Sonoko Sakata contributed equally to this work.

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Author: Kozo Yasui - Sonoko Sakata - Hideaki Ochi - Shinji Itamura - Kenta Hirai - Mieko Takenaka - Osamu Mitani - Kazunori Ogawa

Source: https://link.springer.com/







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