Computer-aided detection in breast MRI: a systematic review and meta-analysisReport as inadecuate

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European Radiology

, Volume 21, Issue 8, pp 1600–1608

First Online: 15 March 2011Received: 10 September 2010Revised: 01 December 2010Accepted: 12 January 2011


ObjectivesTo evaluate the additional value of computer-aided detection CAD in breast MRI by assessing radiologists’ accuracy in discriminating benign from malignant breast lesions.

MethodsA literature search was performed with inclusion of relevant studies using a commercially available CAD system with automatic colour mapping. Two independent researchers assessed the quality of the studies. The accuracy of the radiologists’ performance with and without CAD was presented as pooled sensitivity and specificity.

ResultsOf 587 articles, 10 met the inclusion criteria, all of good methodological quality. Experienced radiologists reached comparable pooled sensitivity and specificity before and after using CAD sensitivity: without CAD: 89%; 95% CI: 78–94%, with CAD: 89%; 95%CI: 81–94% specificity: without CAD: 86%; 95% CI: 79–91%, with CAD: 82%; 95% CI: 76–87%. For residents the pooled sensitivity increased from 72% 95% CI: 62–81% without CAD to 89% 95% CI: 80–94% with CAD, however, not significantly. Concerning specificity, the results were similar without CAD: 79%; 95% CI: 69–86%, with CAD: 78%; 95% CI: 69–84%.

ConclusionsCAD in breast MRI has little influence on the sensitivity and specificity of experienced radiologists and therefore their interpretation remains essential. However, residents or inexperienced radiologists seem to benefit from CAD concerning breast MRI evaluation.

KeywordsMagnetic resonance imaging Breast Computer aided detection CAD Meta-analysis  Download fulltext PDF

Author: Monique D. Dorrius - Marijke C. Jansen-van der Weide - Peter M. A. van Ooijen - Ruud M. Pijnappel - Matthijs Oudkerk


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