Therapeutic promise and challenges of targeting DLL4-NOTCH1Report as inadecuate




Therapeutic promise and challenges of targeting DLL4-NOTCH1 - Download this document for free, or read online. Document in PDF available to download.

Vascular Cell

, 3:17

The Dll4-Notch pathway as a therapeutic target in tumors

Abstract

DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors GSIs might offer insights into how to safely harness this important signaling pathway.

Electronic supplementary materialThe online version of this article doi:10.1186-2045-824X-3-17 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Minhong Yan

Source: https://link.springer.com/article/10.1186/2045-824X-3-17







Related documents