Therapeutic promise and challenges of targeting DLL4-NOTCH1Report as inadecuate

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Vascular Cell

, 3:17

The Dll4-Notch pathway as a therapeutic target in tumors


DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors GSIs might offer insights into how to safely harness this important signaling pathway.

Electronic supplementary materialThe online version of this article doi:10.1186-2045-824X-3-17 contains supplementary material, which is available to authorized users.

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Author: Minhong Yan


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