Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritisReport as inadecuate

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Arthritis Research and Therapy

, 14:R272

First Online: 21 December 2012Received: 15 August 2012Revised: 07 November 2012Accepted: 11 December 2012


IntroductionThe current markers of disease activity in Takayasu arteritis TA are insufficient for proper assessment. We investigated circulating levels of unacylated and acylated ghrelin, leptin and adiponectin and their relationships with disease activity in patients with TA.

MethodsThis study included 31 patients with TA and 32 sex-, age- and body mass index-matched healthy controls. Disease activity was assessed in TA patients using various tools, including Kerr-s criteria, disease extent index-Takayasu, physician-s global assessment, radiological parameters, and laboratory markers. Plasma unacylated and acylated ghrelin, and serum leptin and adiponectin levels were measured using an enzyme-linked immunosorbent assay.

ResultsUnacylated and acylated ghrelin levels were found to be significantly lower in TA patients than that in healthy controls. Patients with active disease had lower unacylated ghrelin levels than those with inactive disease and had lower acylated ghrelin levels than healthy controls. Ghrelin levels were negatively correlated with various parameters of disease activity. The leptin-ghrelin ratio was significantly higher in TA patients than controls. It was positively correlated with disease activity. There was a positive correlation between unacylated and acylated ghrelin and a negative correlation between leptin and ghrelin. There was no statistical difference in adiponectin levels between TA patients and controls. The radiological activity markers were positively correlated with other parameters of disease activity.

ConclusionsThis study suggests that plasma unacylated and acylated ghrelin levels may be useful in monitoring disease activity and planning treatment strategies for patients with TA. The serum leptin level and leptin-ghrelin ratio may also be used to help assess the disease activity.

AbbreviationsACRAmerican College of Rheumatology

ANCAanti-neutrophil cytoplasmic antibody

ASankylosing spondylitis

BMIbody mass index

CRPC- reactive protein

DEI.TakDisease Extent Index-Takayasu

DSAdigital subtraction angiography

ELISAenzyme-linked immunosorbent assay

ESRerythrocyte sedimentation rate

GHgrowth hormone

GHS-Rghrelin receptor-secretagogue receptor

IGF-1insulin-like growth factor 1


IMTintima-media thickness

MRAmagnetic resonance angiography

MRImagnetic resonance imaging

PGAphysician-s global assessment


RArheumatoid arthritis

RANTESregulated and normal T cell-expressed and secreted

SLEsystemic lupus erythematosus

TATakayasu arteritis


TNF-αtumor necrosis factor- alpha


WBCwhite blood cell.

Electronic supplementary materialThe online version of this article doi:10.1186-ar4120 contains supplementary material, which is available to authorized users.

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Author: Hatice Yilmaz - Vedat Gerdan - Didem Kozaci - Dilek Solmaz - Servet Akar - Gercek Can - Aytac Gulcu - Yigit Goktay - Ismai


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