Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort studyReportar como inadecuado

Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medical Imaging

, 11:17

First Online: 24 August 2011Received: 03 May 2011Accepted: 24 August 2011


BackgroundThere is recent interest in the role of carotid bifurcation anatomy, geometry and hemodynamic factors in the pathogenesis of carotid artery atherosclerosis. Certain anatomical and geometric configurations at the carotid bifurcation have been linked to disturbed flow. It has been proposed that vascular dimensions are selected to minimize energy required to maintain blood flow, and that this occurs when an exponent of 3 relates the radii of parent and daughter arteries. We evaluate whether the dimensions of bifurcation of the extracranial carotid artery follow this principle of minimum work.

MethodsThis study involved subjects who had computed tomographic angiography CTA at our institution between 2006 and 2007. Radii of the common, internal and external carotid arteries were determined. The exponent was determined for individual bifurcations using numerical methods and for the sample using nonlinear regression.

ResultsMean age for 45 participants was 56.9 ± 16.5 years with 26 males. Prevalence of vascular risk factors was: hypertension-48%, smoking-23%, diabetes-16.7%, hyperlipidemia-51%, ischemic heart disease-18.7%.

The value of the exponent ranged from 1.3 to 1.6, depending on estimation methodology.

ConclusionsThe principle of minimum work defined by an exponent of 3 may not apply at the carotid bifurcation. Additional factors may play a role in the relationship between the radii of the parent and daughter vessels.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2342-11-17 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Documentos relacionados