Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studiesReportar como inadecuado




Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 38, Issue 9, pp 1636–1647

First Online: 27 May 2011Received: 21 January 2011Accepted: 09 May 2011

Abstract

PurposeStandardized uptake values SUV are commonly used for quantification of whole-body Ffluoro-2-deoxy-D-glucose FDG positron emission tomography PET studies. Changes in SUV following therapy, however, only provide a proper measure of response in case of homogeneous FDG uptake in the tumour. The purpose of this study was therefore to implement and characterize a method that enables quantification of heterogeneity in tumour FDG uptake.

MethodsCumulative SUV-volume histograms CSH, describing % of total tumour volume above % threshold of maximum SUV SUVmax, were calculated. The area under a CSH curve AUC is a quantitative index of tumour uptake heterogeneity, with lower AUC corresponding to higher degrees of heterogeneity. Simulations of homogeneous and heterogeneous responses were performed to assess the value of AUC-CSH for measuring uptake and-or response heterogeneity. In addition, partial volume correction and image denoising was applied prior to calculating AUC-CSH. Finally, the method was applied to a number of human FDG scans.

ResultsPartial volume correction and noise reduction improved CSH curves. Both simulations and clinical examples showed that AUC-CSH values corresponded with level of tumour heterogeneity and-or heterogeneity in response. In contrast, this correspondence was not seen with SUVmax alone. The results indicate that the main advantage of AUC-CSH above other measures, such as 1-COV coefficient of variation, is the possibility to measure or normalize AUC-CSH in different ways.

ConclusionAUC-CSH might be used as a quantitative index of heterogeneity in tracer uptake. In response monitoring studies it can be used to address heterogeneity in response.

KeywordsPositron emission tomography PET Standardized uptake value SUV Intratumoural heterogeneity Cumulative SUV-volume histogram CSH Intensity-volume histograms IVH  Download fulltext PDF



Autor: Floris H. P. van Velden - Patsuree Cheebsumon - Maqsood Yaqub - Egbert F. Smit - Otto S. Hoekstra - Adriaan A. Lammert

Fuente: https://link.springer.com/







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