Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility studyReportar como inadecuado




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European Radiology

, Volume 21, Issue 9, pp 1811–1819

First Online: 15 May 2011Received: 12 October 2010Revised: 15 January 2011Accepted: 18 February 2011

Abstract

ObjectivesValidation of the feasibility and efficacy of volume perfusion computed tomography VPCT in the preoperative assessment of cerebral gliomas by applying a 128-slice CT covering the entire tumour.

MethodsForty-six patients 25 men, 21 women; mean age 52.8 years with cerebral gliomas were evaluated with VPCT. Two readers independently evaluated VPCT data, drawing volumes of interest VOIs around the tumour according to maximum intensity projection volumes, which were mapped automatically onto the cerebral blood volume CBV, flow CBF and permeability Ktrans perfusion datasets. As control, a second VOI was placed in the contralateral healthy cortex. Correlation among perfusion parameters, tumour grade, hemisphere and VOIs was assessed. The diagnostic power of perfusion parameters was analysed by receiver operating characteristics curve analyses.

ResultsVPCT was feasible in the assessment of the entire tumour extent. Mean values of Ktrans, CBV, CBF in high-grade gliomas were significantly higher compared with low-grade p < 0.01. Ktrans demonstrated the highest diagnostic 97% sensitivity, positive 100% and negative 94% prognostic values.

ConclusionsVPCT was feasible in all subjects. All areas of different perfusion characteristics are depicted and quantified in colour-coded 3D maps. The derived parameters correlate well with tumour histopathology, differentiating low- from high-grade gliomas.

KeywordsCone-beam computed tomography Brain neoplasms Glioma Feasibility studies  Download fulltext PDF



Autor: Argyro Xyda - Ulrike Haberland - Ernst Klotz - Hans Christoph Bock - Klaus Jung - Michael Knauth - Ramona Schramm - Marios

Fuente: https://link.springer.com/



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