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BMC Musculoskeletal Disorders

, 14:3

Clinical diagnostics and imaging

Abstract

BackgroundTo determine the validity of a semi-automated segmentation of bone marrow lesions BMLs in the knee.

MethodsConstruct validity of the semi-automated BML segmentation method was explored in two studies performed using sagittal intermediate weighted, turbo spine echo, fat-suppressed magnetic resonance imaging sequences obtained from the Osteoarthritis Initiative. The first study n = 48 evaluated whether tibia BML volume was different across Boston Leeds Osteoarthritis Knee Scores BLOKS for tibia BMLs semiquantitative grades 0 to 3. In the second study n = 40, we evaluated whether BML volume change was associated with changes in cartilage parameters. The knees in both studies were segmented by one investigator. We performed Wilcoxon signed-rank tests to determine if tibia BML volume was different between adjacent BLOKS BML scores and calculated Spearman correlation coefficients to assess the relationship between 2-year BML volume change and 2-year cartilage morphometry change significance was p ≤ 0.05.

ResultsBML volume was significantly greater between BLOKS BML score 0 and 1 z = 2.85, p = 0.004 and BLOKS BML scores 1 and 2 z = 3.09, p = 0.002. There was no significant difference between BLOKS BML scores 2 and 3 z = −0.30, p = 0.77. Increased tibia BML volume was significantly related to increased tibia denuded area Spearman r = 0.42, p = 0.008, decreased tibia cartilage thickness Spearman r = −0.46, p = 0.004, increased femur denuded area Spearman r = 0.35, p = 0.03, and possibly decreased femur cartilage thickness Spearman r = −0.30, p = 0.07 but this last finding was not statistically significant.

ConclusionThe new, efficient, and reliable semi-automated BML segmentation method provides valid BML volume measurements that increase with greater BLOKS BML scores and confirms previous reports that BML size is associated with longitudinal cartilage loss.

KeywordsKnee Magnetic resonance imaging Osteoarthritis AbbreviationsBLOKSBoston Leeds Osteoarthritis Knee Scores

BMLBone marrow lesion

FDRFalse Detection Rate

ICCIntra-class correlation coefficient

MRMagnetic resonance

OAOsteoarthritis

OAIOsteoarthritis Initiative

μLength penalty parameter.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2474-14-3 contains supplementary material, which is available to authorized users.

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Autor: Jincheng Pang - Jeffrey B Driban - Geoffroy Destenaves - Eric Miller - Grace H Lo - Robert J Ward - Lori Lyn Price - Jo

Fuente: https://link.springer.com/







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