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Current Rheumatology Reports

, 15:342

Topical Collection on Seronegative Arthritis

Abstract

The seronegative spondyloarthopathies SpA share certain common articular and peri-articular features that differ from rheumatoid arthritis RA and other forms of inflammatory arthritis. These include the tendency of the SpAs to involve the axial skeleton in addition to the diarthrodial joints, and the prominent involvement of the extra-articular entheses sites of ligamentous and tendon insertion, which are not common sites of primary pathology in RA and other inflammatory arthropathies. The differential anatomic sites of bone pathology in the SpAs in comparison to the other forms of arthritis suggest that the underlying pathogenic processes and cellular and molecular mechanisms that account for the peri-articular bone pathology involve different underlying disease mechanisms. This review will highlight the molecular and cellular processes that are involved in the pathogenesis of the skeletal pathology in the SpAs, and provide evidence that many of the factors involved in regulation of bone cell function exhibit potent immune-regulatory activity, providing support for the general concept of osteoimmunology.

KeywordsOsteoimmunology Bone homeostasis Spondyloarthritis Ankylosing spondylitis Psoriatic arthritis Osteoclast Osteoblast Osteocyte Bone remodeling Inflammation Cytokine Bone morphogenic proteins Wnt-βcatenin Sclerostin This article is part of the Topical Collection on Seronegative Arthritis

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Autor: Steven R. Goldring

Fuente: https://link.springer.com/







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