Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetesReportar como inadecuado




Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Cardiovascular Diabetology

, 11:21

First Online: 07 March 2012Received: 14 November 2011Accepted: 07 March 2012

Abstract

BackgroundMeta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease CAD. Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by oxidative stress. We hypothesized that postchallenge proinflammatory and nitrosative responses after 75 g oral glucose tolerance tests 75 g-OGTT might be associated with CAD in patients without previously recognized type 2 diabetes mellitus T2DM.

MethodsSerial changes of plasma glucose PG, tumor necrosis factor-alpha TNF-α, interleukin-6 IL-6 and nitrotyrosine levels were analyzed during 75 g-OGTT in 120 patients 81 male; age 62 ± 11 years before coronary angiography. Patients were classified as normal NGT; 42%, impaired IGT; 34% and diabetic T2DM; 24% glucose tolerance by 75 g-OGTT.

ResultsPostchallenge hyperglycemia elicited TNF-α, IL-6 and nitrotyrosine levels time-dependently, and 2-hr median levels of TNF-α 7.1 versus 6.4 pg-ml; P < 0.05 and nitrotyrosine 1.01 versus 0.83 μ mol-l; P < 0.05, but not IL-6 or PG, were significantly higher in patients with CAD in either IGT or T2DM groups. After adjusting risk factors and glucose tolerance status, 2-hr nitrotyrosine in highest quartiles OR: 3.1, P < 0.05 remained an independent predictor of CAD by logistic regression analysis.

ConclusionsThese results highlight postchallenge proinflammatory and nitrosative responses by 75 g-OGTT, rather than hyperglycemia per se, are associated with CAD in patients without previous recognized diabetes.

KeywordsPostchallenge hyperglycemia Inflammation Oxidative stress Nitrotyrosine oral Glucose tolerance test Coronary artery disease Abbreviations75 g-OGTT75 g oral glucose tolerance test

CADCoronary artery disease

IGTImpaired glucose tolerance

IL-6Interleukin-6

NGTNormal glucose tolerance

PGPlasma glucose

TNF-αTumor necrosis factor-alpha

T2DMType 2 diabetes mellitus.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-11-21 contains supplementary material, which is available to authorized users.

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Autor: Chih-Sheng Chu - Kun-Tai Lee - Kai-Hong Cheng - Min-Yi Lee - Hsuan-Fu Kuo - Tsung-Hsien Lin - Ho-Ming Su - Wen-Chol Voon -

Fuente: https://link.springer.com/article/10.1186/1475-2840-11-21







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