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Cardiovascular Diabetology

, 11:20

First Online: 07 March 2012Received: 15 December 2011Accepted: 07 March 2012


BackgroundVisceral adiposity index VAI has recently been suggested to be used as a surrogate of visceral adiposity. We examined if VAI could improve predictive performances for CVD of the Framingham-s general CVD algorithm a multivariate model incorporating established CVD risk factors. We compared the predictive abilities of the VAI with those of simple anthropometric measures i.e. BMI, waist-to-height ratio WHtR or waist-to-hip ratio WHpR.

Design and methodsIn a nine-year population-based follow-up, 6 407 2 778 men participants, free of CVD at baseline, aged ≥ 30 years were eligible for the current analysis. The risk of CVD was estimated by incorporating VAI, BMI, WHpR, and WHtR, one at a time, into multivariate accelerated failure time models.

ResultsWe documented 534 CVD events with the annual incidence rate 95%CIs being 7.3 6.4-8.3 among women and 13.0 11.7-14.6 among men. Risk of future CVD increased with increasing levels of VAI among both men and women. VAI was associated with multivariate-adjusted increased risk of incident CVD among women. However, the magnitude of risk conferred by VAI was not significantly higher than those conferred by BMI, WHpR, or WHtR. Among men, after adjustment for established CVD risk factors, VAI was no longer associated with increased risk of CVD. VAI failed to add to the predictive ability of the Framingham general CVD algorithm.

ConclusionsUsing VAI instead of simple anthropometric measures may lead to loss of much information needed for predicting incident CVD.

KeywordsBody mass index Cardiovascular disease Prediction Visceral adiposity index Waist- to-height ratio Waist-to-hip ratio AbbreviationsBMIBody mass index

CHDCoronary heart disease

CVDCardiovascular disease

CTBy computed tomography


HDL-CHigh-density lipoprotein cholesterol

MIMyocardial infarction

MRIMagnetic resonance imaging


TLGSTehran lipid and glucose study

VAIVisceral adiposity index

VIFVariance inflation factor

WCWaist circumference

WHpRWaist-to-hip ratio

WHtRWaist-to-height ratio.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-11-20 contains supplementary material, which is available to authorized users.

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Autor: Bozorgmanesh Mohammadreza - Hadaegh Farzad - Khalili Davoud - Azizi Fereidoun Prof


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