Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distributionReportar como inadecuado

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Cardiovascular Diabetology

, 11:22

First Online: 07 March 2012Received: 19 January 2012Accepted: 07 March 2012


BackgroundB-type natriuretic peptide BNP, a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is associated with atherosclerotic cardiovascular diseases and cardiac dysfunction. Circulating BNP levels are relatively low within the normal limits in obesity and the metabolic syndrome. However, the relationship between plasma BNP levels and visceral fat accumulation in general population has not been reported. The present study analyzed the relationships between plasma BNP levels and various clinical variables, including insulin, visceral and subcutaneous fat area VFA and SFA, respectively, in normal Japanese men.

MethodsThe study Victor-J study subjects were consecutive 500 Japanese male workers, who underwent a health checkup and were measured VFA and SFA by computed tomography.

ResultsAge-adjusted simple linear regression analysis showed that log-BNP correlated positively with HDL-cholesterol, and negatively with VFA, log-immunoreactive insulin IRI, log-triglyceride, and LDL-cholesterol, but not body mass index or SFA. Stepwise multiple regression analysis identified log-IRI and HDL-cholesterol as significant determinants of log-BNP. Subjects with IRI ≥5.5 μIU-mL had lower plasma BNP levels than those with IRI < 5.5 μIU-mL, irrespective of obesity body mass index, cutoff value 25 kg-m, visceral fat accumulation VFA, cutoff value 100 cm and subcutaneous fat accumulation SFA, cutoff value 128 cm.

ConclusionsOur study showed that hyperinsulinemia correlated with low levels of plasma BNP in general men, irrespective of fat distribution.

Trial registrationUMIN 000004318.

KeywordsB-type natriuretic peptide Hyperinsulinemia Visceral fat AbbreviationsBNPB-type natriuretic peptide

CTComputed tomography

IRIImmunoreactive insulin

NEPNeutral endopeptidase

NPNatriuretic peptide

NPRNatriuretic peptide receptor

SFASubcutaneous fat area

VFAVisceral fat area.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-11-22 contains supplementary material, which is available to authorized users.

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Autor: Hideaki Nakatsuji - Ken Kishida - Tohru Funahashi - Tohru Nakagawa - Iichiro Shimomura

Fuente: https://link.springer.com/article/10.1186/1475-2840-11-22

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