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Cardiovascular Diabetology

, 11:23

First Online: 09 March 2012Received: 09 February 2012Accepted: 09 March 2012

Abstract

BackgroundPremature ventricular complexes PVC predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium Mg depletion studies in adults. We thus hypothesized that serum magnesium sMg concentrations are inversely associated with the prevalence of PVC in adults at high cardiovascular risk.

MethodsAnthropometric, demographic and lifestyle characteristics were assessed in 750 Cree adults, aged > 18 yrs, who participated in an age-stratified, cross-sectional health survey in Quebec, Canada. Holter electrocardiograms recorded heart rate variability and cardiac arrhythmias for two consecutive hours. Multivariate logistic regression was used to evaluate the associations between sMg and PVC.

ResultsPVC prevalence in adults with hypomagnesemia sMg ≤ 0.70 mmol-L was more than twice that of adults without hypomagnesemia 50% vs. 21%, p = 0.015; results were similar when adults with cardiovascular disease history were excluded. All hypomagnesemic adults with PVC had type 2 diabetes T2DM. Prevalence of PVC declined across the sMg concentration gradient in adults with T2DM only p < 0.001 for linear trend. In multivariate logistic regressions adjusted for age, sex, community, body mass index, smoking, physical activity, alcohol consumption, kidney disease, antihypertensive and cholesterol lowering drug use, and blood docosahexaenoic acid concentrations, the odds ratio of PVC among T2DM subjects with sMg > 0.70 mmol-L was 0.24 95% CI: 0.06-0.98 p = 0.046 compared to those with sMg ≤ 0.70 mmol-L.

ConclusionssMg concentrations were inversely associated with the prevalence of PVC in patients with T2DM in a dose response manner, indicating that suboptimal sMg may be a contributor to arrhythmias among patients with T2DM.

KeywordsMagnesium Hypomagnesemia Premature ventricular complexes Premature ventricular beats Ectopic beats Arrhythmia Type 2 diabetes AbbreviationsACCAmerican College of cardiology

AHAAmerican heart association

ARICAtherosclerosis risk in communities

BMIBody mass index

CVDCardiovascular event or conditions

CIConfidence interval

CBHSSJBCree board of health and social services of James bay

DHADocosahexaenoic acid

EPAEicosapentaenoic acid

ESCEuropean society of cardiology

FGFasting glucose

HRHazard ratio

IDFInternational diabetes federation

MgMagnesium

MetSMetabolic syndrome

OROdds ratio

PVCPremature ventricular complexes

sMgTotal serum magnesium

T2DMType 2 diabetes mellitus

USDAUnited states department of agriculture.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-11-23 contains supplementary material, which is available to authorized users.

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Autor: Liana C Del Gobbo - Yiqing Song - Paul Poirier - Eric Dewailly - Ronald J Elin - Grace M Egeland

Fuente: https://link.springer.com/article/10.1186/1475-2840-11-23



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