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Current Rheumatology Reports

, 15:385

Topical Collection on Osteoarthritis


Biological therapy is a thriving area of research and development, and is well established for chronic forms of rheumatoid arthritis RA and ankylosing spondylitis AS. However, there is no clinically validated biological therapy for osteoarthritis OA. Chronic forms of OA are increasingly viewed as an inflammatory disease. OA was largely regarded as a -wear and tear disease-. However, the disease is now believed to involve -low grade- inflammation and the growth of blood vessels and nerves from the subchondral bone into articular cartilage. This realization has focused research effort on the development and evaluation of biological therapy that targets proinflammatory mediators, angiogenic factors and cytokines in articular cartilage, subchondral bone and synovium in chronic forms of OA. This review article provides an overview of emerging biological therapy for OA, and discusses recent molecular targets implicated in angiogenesis and neurogenesis and progress with antibody-based therapy, calcitonin, and kartogenin, the small molecule stimulator of chondrogenesis.

KeywordsOsteoarthritis Therapeutics Biological therapy Therapeutic antibodies Calcitonin Kartogenin Fibroblast growth factor 18 FGF-18 Anticytokine therapy Angiogenesis Neurogenesis DMOADs DMARDs This article is part of the Topical Collection on Osteoarthritis

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Autor: A. Mobasheri


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