Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical diseaseReportar como inadecuado




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Arthritis Research and Therapy

, 15:122

First Online: 30 October 2013

Abstract

Rheumatoid arthritis, currently regarded as a complex multifactorial disease, was initially characterized as such at the turn of the 19th century. Ever since, multiple lines of investigation have attempted to elucidate the etiological factors involved in disease incidence. Genes – including those risk alleles within HLA-DR4 – have been implicated but are insufficient to explain the vast majority of cases. Several environmental factors, therefore, are being studied. Among them, the role of periodontal disease and Porphyromonas gingivalis in the pathogenesis of rheumatoid arthritis has attracted both clinical and bench interest given supportive epidemiologic and mechanistic data.

AbbreviationsACPAAntibody to citrullinated protein antigens

DMARDDisease-modifying anti-rheumatic drug

PADPeptydil arginine deiminase

RARheumatoid arthritis.

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Autor: Jose U Scher - Steven B Abramson

Fuente: https://link.springer.com/



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