Exercise capacity in relation to autoantibodies in systemic sclerosis patientsReportar como inadecuado




Exercise capacity in relation to autoantibodies in systemic sclerosis patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Rheumatology International

, Volume 33, Issue 11, pp 2913–2916

First Online: 05 November 2012Received: 15 March 2012Accepted: 21 October 2012

Abstract

Autoantibodies have been detected in systemic sclerosis patients, and typical clinical features regarding organ involvement by each autoantibody have been reported. To reveal differences in exercise intolerance in patients with either anti-topoisomerase-I or anti-centromere antibodies, 53 systemic sclerosis patients were investigated retrospectively. A 6-min walking distance showed no significant differences P = 0.090 between autoantibodies, while exercise-induced hypoxia during the 6-min walking test was significant in subjects with the anti-topoisomerase-I antibody P = 0.033. The percent predicted of vital capacity, the diffusion capacity of the lung for carbon monoxide, and the modified Rodnan skin score were affected more in subjects with the anti-topoisomerase-I antibody than the anti-centromere antibody. The main parameter affecting the 6-min walking distance was the percent predicted of vital capacity for each autoantibody, and there was a significant positive relationship for all subjects R = 0.30, P < 0.0001. Exercise-induced hypoxia was also shown in the more affected subjects in the percent predicted of vital capacity and the diffusion capacity of the lung for carbon monoxide. Lung parameters were suggested to be more important factors determining exercise intolerance and induced hypoxia than detected autoantibodies.

KeywordsSystemic sclerosis 6-Min walking test Autoantibody Lung function Oxygen saturation  Download fulltext PDF



Autor: Fujiko Someya - Naoki Mugii - Tetsutarou Yahata - Takao Nakagawa

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados