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European Journal of Nuclear Medicine and Molecular Imaging

, Volume 39, Issue 6, pp 1065–1069

First Online: 13 March 2012Received: 19 December 2011Accepted: 07 February 2012

Abstract

BackgroundDeterioration of left ventricular LV function after myocardial infarction MI is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve MPR and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively.

MethodsRegional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress N-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening.

ResultsNormal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments p < 0.001. Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional p < 0.001.

ConclusionThis study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI.

KeywordsMyocardial infarction Left ventricular function Myocardial perfusion imaging Cardiac MRI  Download fulltext PDF



Autor: Riemer H. J. A. Slart - Julius Glauche - Reza Golestani - Clark J. Zeebregts - Jan W. Jansen - Rudi A. J. O. Dierckx

Fuente: https://link.springer.com/







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