Reduced 30-day mortality in men after elective coronary artery bypass surgery with minimized extracorporeal circulation-a propensity score analysisReportar como inadecuado




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BMC Cardiovascular Disorders

, 12:17

First Online: 16 March 2012Received: 22 October 2011Accepted: 16 March 2012

Abstract

BackgroundImpact of minimized extracorporeal circulation MECC for coronary surgery on mortality remains controversial and gender significantly influence outcome.

MethodsWe analyzed 3,139 male patients undergoing elective coronary surgery between 01-2004 and 05-2009. Using propensity score matching after binary logistic regression, 1,005 patients from 1,119 patients undergoing surgery with MECC could be matched with 1,005 patients from 2,020 patients undergoing surgery with conventional extracorporeal circulation CECC. Primary outcome was 30-day mortality.

ResultsUnadjusted 30-day mortality was 2.7% in patients with CECC and 0.8% in those with MECC mean difference -1.9%; p < 0.001. The adjusted mean difference average treatment effect of the treated after matching was -1.5% 95% confidence interval CI -2.6 to -0.4; p = 0.006. Postoperative hospital stay was shorter in patients operated with minimized systems adjusted mean difference -0.8 days; 95% CI -1.46 to -0.09; p = 0.03 and incidence of postoperative neurocognitive dysfunction was also lower adjusted mean difference -1.3%; 95% CI -2.2 to -0.4; p = 0.001. Chest tube drainage adjusted mean difference +22 mL; 95% CI -47 to 91; p = 0.5 and risk for acute kidney injury, kidney injury and failure according to RIFLE criteria adjusted mean difference -1.0%; 95% CI -2.5 to 0.6; p = 0.24 proved to be insignificant between both groups. Apart from reduced 30-day mortality, however, average treatment effects for intensive care unit stay, postoperative hospital stay, chest tube drainage and kidney injury did not significantly differ.

ConclusionUsing propensity score analysis, we observed an association between MECC and reduced 30-day mortality in men, but our results call for further analysis.

KeywordsOutcome Men MECC CABG Mortality Propensity score analysis Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-12-17 contains supplementary material, which is available to authorized users.

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Autor: Michael Ried - Reinhard Kobuch - Leopold Rupprecht - Andreas Keyser - Michael Hilker - Christof Schmid - Claudius Diez

Fuente: https://link.springer.com/article/10.1186/1471-2261-12-17



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