The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart diseaseReportar como inadecuado




The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Cardiovascular Diabetology

, 11:115

First Online: 25 September 2012Received: 04 July 2012Accepted: 10 September 2012

Abstract

BackgroundVisceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue MAT and epicardial adipose tissue EAT, and MAT is a potential biomarker of risk for obese patients.

AimOur objective was to evaluate the role of EAT and MAT 11beta-hydroxysteroid dehydrogenase type 1 11β-HSD-1 and glucocorticoid receptor GCR expression in comparison with subcutaneous adipose tissue SAT in the development of coronary atherosclerosis in obese patients with coronary artery disease CAD, and to assess their correlations with CD68 and fatty acids from these tissues.

Methods and resultsExpression of 11β-HSD-1 and GCR was measured by qRT-PCR in EAT, MAT and SAT of thirty-one obese patients undergoing coronary artery bypass grafting due to CAD obese CAD group and sixteen obese patients without CAD undergoing heart valve surgery controls. 11β-HSD-1 and GCR expression in MAT were found to be significantly increased in the obese CAD group compared with controls p < 0.05. In the obese CAD group, 11β-HSD-1 and GCR mRNA levels were strongly correlated in MAT. Stearidonic acid was significantly increased in EAT and MAT of the obese CAD group and arachidonic acid was significantly expressed in MAT of the obese male CAD group p < 0.05.

ConclusionsWe report for the first time the increased expression of 11β-HSD-1 and GCR in MAT compared with EAT and SAT, and also describe the interrelated effects of stearidonic acid, HOMA-IR, plasma cortisol and GCR mRNA levels, explaining 40.2% of the variance in 11β-HSD-1 mRNA levels in MAT of obese CAD patients. These findings support the hypothesis that MAT contributes locally to the development of coronary atherosclerosis via glucocorticoid action.

KeywordsMediastinal adipose tissue Glucocorticoid Inflammation Coronary artery disease Stearidonic acid Cortisol AbbreviationsMATMediastinal adipose tissue

EATEpicardial adipose tissue

SATSubcutaneous adipose tissue

CADCoronary artery disease

11β-HSD-111beta-hydroxysteroid dehydrogenase type 1

GCRGlucocorticoid receptor

CABGCoronary artery bypass grafting

FFAFree fatty acid.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-11-115 contains supplementary material, which is available to authorized users.

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Autor: Fatmahan Atalar - Selcuk Gormez - Baris Caynak - Gokce Akan - Gamze Tanriverdi - Sema Bilgic-Gazioglu - Demet Gunay - Cihan

Fuente: https://link.springer.com/article/10.1186/1475-2840-11-115



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