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Vascular Cell

, 4:16

First Online: 01 October 2012Received: 03 January 2012Accepted: 21 August 2012

Abstract

BackgroundThe current knowledge on molecular pathogenesis of cerebral vascular malformations CVM, which are believed to arise during development, is very limited. To unravel the molecular mechanisms involved in CVMs, a detailed understanding of the brain vascular development at molecular level is crucial. In this study, we aimed to explore the temporal and comparative expression profile of angiogenesis-related genes in the establishment of brain vasculature.

MethodsExpression of a total of 113 angiogenesis-related genes during murine brain development has been analyzed using low-density array systems designed for angiogenesis-related genes. Bai1 brain specific angiogenesis inhibitor-1, a recently identified novel anti-angiogenic gene, has been selected for further characterization.

ResultsWe found that 62 out of 113 analyzed genes have expression in brain development at varying levels. Nineteen of these were differentially expressed between embryonic and postnatal stages >1.5 fold. Bai1 is strongly expressed on growing blood vessels of cerebral cortex and hippocampus, partially expressed in the lateral regions of striatum, but mostly absent on the thalamus.

ConclusionBy showing the comparative expression analysis of angiogenesis-related genes throughout brain development, the data presented here will be a crucial addition to further functional studies on cerebrovascular research.

KeywordsCerebrovascular development Arteriovenous malformations Angiogenesis Bai1 Electronic supplementary materialThe online version of this article doi:10.1186-2045-824X-4-16 contains supplementary material, which is available to authorized users.

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Autor: Abdulkadir Özkan - Atilla Biçer - Timuçin Avşar - Aşkın Şeker - Zafer Orkun Toktaş - Süheyla Uyar Bozkurt - Ayşe

Fuente: https://link.springer.com/article/10.1186/2045-824X-4-16



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