Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumoursReport as inadecuate

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European Journal of Nuclear Medicine and Molecular Imaging

, Volume 39, Issue 11, pp 1691–1701

First Online: 27 June 2012Received: 10 November 2011Accepted: 04 June 2012


PurposePerfusion CT PCT measurements of regional cerebral blood flow rCBF have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with O-labelled water O-H2O.

MethodsOn the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using O-H2O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared.

ResultsPCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min 100 ml for PET and 78.9 ± 41.8 ml min 100 ml for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min 100 ml for low-grade WHO I + II and 81.5 ± 15.4 ml min 100 ml for high-grade WHO III + IV tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients.

ConclusionAlthough intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and O-H2O PET in brain tumours.

KeywordsPET Brain perfusion Brain tumour Oxygen radioisotopes Perfusion CT  Download fulltext PDF

Author: Julie Marie Grüner - Rune Paamand - Michael Kosteljanetz - Helle Broholm - Liselotte Højgaard - Ian Law


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