Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy peopleReport as inadecuate

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Cardiovascular Ultrasound

, 10:39

First Online: 02 October 2012Received: 28 August 2012Accepted: 28 September 2012


BackgroundAlthough chronic effects of exercise on endothelial function are established, the impact of acute exercise on flow-mediated dilatation FMD of brachial artery has not been elucidated yet.

MethodsEighty-six young healthy volunteers were prospectively enrolled from January 2011 to December 2011. The subjects completed FMD tests at rest and immediately after treadmill exercise test. Primary outcome was the impact of acute exercise on FMD, measured by the difference of FMD before and after exercise. Secondary outcomes were the relationship of gender and exercise habit with FMD.

ResultsSeventy-four subjects who met the eligibility criteria were included for analysis. Thirty-five 47.3% were male, and the mean age was 22.7±2.7 years. FMD was reduced after exercise 8.98±4.69 to 7.51±4.03%; P=0.017 and the reduction was found in female group 10.36±5.26 to 7.62±3.71%; P=0.002 but not in male group. Post-exercise FMD was significantly impaired in subjects who did not exercise regularly 6.92±3.13% versus 8.95±5.33%; P=0.003. The decrease of FMD after exercise was greater in female group −2.75±5.28% versus 0.27±3.24%; P=0.003 and was associated with exercise habit β=2.532; P=0.027.

ConclusionsIn healthy young subjects, FMD was reduced after a bout of acute exercise. The impact of acute exercise showed significant differences according to gender and exercise habit. FMD impairment after acute exercise was observed in females and subjects without regular exercise.

KeywordsFlow-mediated dilatation FMD Acute exercise AbbreviationsANCOVAAnalysis of covariance

BMIBody mass index

CADCoronary artery disease

CIConfidence interval

DMDiabetes mellitus

FMDFlow-mediated dilatation

HDL-CHigh-density lipoprotein-cholesterol

IQRInterquartile range

LDL-CLow-density lipoprotein-cholesterol

NONitric oxide

SDStandard deviation

RM-ANCOVARepeated measure analysis of covariance.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-7120-10-39 contains supplementary material, which is available to authorized users.

In-Chang Hwang, Kyung-Hee Kim contributed equally to this work.

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Author: In-Chang Hwang - Kyung-Hee Kim - Won-Suk Choi - Hyun-Jin Kim - Moon-Sun Im - Yong-Jin Kim - Sang-Hyun Kim - Myung-A Kim -


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