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BMC Cardiovascular Disorders

, 12:85

First Online: 02 October 2012Received: 30 May 2012Accepted: 20 September 2012


BackgroundAtrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and the associated health outcomes.

Methods-designRHYTHM-AF was a prospective observational multinational study of management of recent onset atrial fibrillation patients considered for cardioversion designed to collect data on international treatment patterns and short term outcomes related to cardioversion. We present data collected in 10 countries between May 2010 and June 2011. Enrollment was ongoing in Italy and Brazil at the time of data analysis. Data were collected at the time of atrial fibrillation episode in all countries Australia, Brazil, France, Germany, Italy, Netherlands, Poland, Spain, Sweden, United Kingdom, and cumulative follow-up data were collected at day 60 ±10 in all but Spain. Information on center characteristics, enrollment data, patient demographics, detail of atrial fibrillation episode, medical history, diagnostic procedures, acute treatment of atrial fibrillation, discharge information and the follow-up data on major events and rehospitalizations up to day 60 were collected.

DiscussionA total of 3940 patients were enrolled from 175 acute care centers. 70.5% of the centers were either academic 44% or teaching 26% hospitals with an overall median capacity of 510 beds. The sites were mostly specialized with anticoagulation clinics 65.9%, heart failure 75.1% and hypertension clinics 60.1% available. The RHYTHM-AF registry will provide insight into regional variability of antiarrhythmic and antithrombotic treatment of atrial fibrillation, the appropriateness of such treatments with respect to outcomes, and their cost-efficacy. Observations will help inform strategies to improve cardiovascular outcomes in patients with atrial fibrillation.

Trial registrationClinical trials NCT01119716

KeywordsAtrial fibrillation Cardioversion Heart failure Stroke Registry AbbreviationsAFAtrial fibrillation

PCVPharmacological cardioversion

ECVElectrical cardioversion

ESCEuropean Society of Cardiology

eCRFElectronic case report form


TEETransesophageal echocardiogram.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-12-85 contains supplementary material, which is available to authorized users.

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Fuente: https://link.springer.com/article/10.1186/1471-2261-12-85

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