The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensusReportar como inadecuado

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* Corresponding author 1 Department of Radiation Oncology 2 Institut Langevin ondes et images 3 Radiological Sciences Laboratory 4 Imaging Division 5 Division of Radiotherapy and Imaging 6 Faculty of Medicine 7 Philips Healthcare 8 Ultrasound Innovations Applications 9 InSightec Ltd 10 Chongqing Haifu Medical Technology Co. 11 Focused Ultrasound Foundation 12 Università degli Studi di Roma -La Sapienza- Rome 13 Digestive Disease Center 14 Institute of Ultrasonic Engineering in Medicine 15 Clinical Center for Tumor Therapy 16 Institute for Medical Science and Technology 17 Department of Radiology 18 Department of Medicine 19 Saint Mary-s Hospital London

Abstract : Clinical use of high-intensity focused ultrasound HIFU under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods- clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion-flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.

Keywords : Ultrasound Non-invasive surgery High-intensity ultrasound Focused ultrasound Liver cancer

Autor: Jean-Francois Aubry - Kim Pauly - Chrit Moonen - Gail Ter Haar - Mario Ries - Rares Salomir - Sham Sokka - Kevin Sekins - Yerucha



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