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Autoimmune DiseasesVolume 2012 2012, Article ID 784315, 12 pages

Review Article

Rheumatology Unit, Fundación Valle del Lili, ICESI University, Avenida Simón Bolívar Cra. 98 No.18-49, Cali, Colombia

Fundación Valle del Lili, Medical School, Universidad del Valle, Cali, Colombia

Received 14 September 2011; Accepted 28 December 2011

Academic Editor: Juan-Manuel Anaya

Copyright © 2012 Carlos A. Cañas and Felipe Cañas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is an inherent part of living to be in constant modification, which are due to answers resulting from environmental changes. The different systems make adaptations based on natural selection. With respect to the immune system of mammals, these changes have a lot to do with the interactions that occur continuously with other living species, especially microorganisms. The immune system is primarily designed to defend from germs and this response triggers inflammatory reactions which must be regulated in order not to generate damage to healthy tissue. The regulatory processes were added over time to prevent such damage. Through evolution the species have stored “an immunological experience,” which provides information that is important for developing effective responses in the future. The human species, which is at a high level of evolutionary immunological accumulation, have multiple immune defense strategies which, in turn, are highly regulated. Imbalances in these can result in autoimmunity.

“There is nothing permanent except change.”Heraclitus

Autor: Carlos A. Cañas and Felipe Cañas



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