Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema ModelReportar como inadecuado




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Inflammation

, Volume 37, Issue 1, pp 1–9

First Online: 05 September 2013

Abstract

The study was aimed to investigate the effect of technologically treated diclofenac release-active dilutions of diclofenac RAD of diclofenac on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats 6–8 weeks divided into nine groups n = 10 were used. Anti-inflammatory activity was assessed at 1, 2, 3, 4, and 6 h after subplantar injection of carrageenan 0.1 ml of a 1 % solution in normal saline. Diclofenac alone was studied at 5 and 20 mg-kg, RAD of diclofenac alone at 7.5 ml-kg and their combination at 5 and 7.5 ml-kg, respectively. Diclofenac reduced p < 0.05 at least paw edema at all time points. RAD of diclofenac enhanced p < 0.05 anti-inflammatory effect of diclofenac 5 mg-kg at 2, 4, and 6 h on concurrent and at 2 and 4 h on sequential administration. Moreover at 2 h, anti-inflammatory effect of combination treatment reached values comparable to those of diclofenac 20 mg-kg. In conclusion, RAD of diclofenac enhanced anti-inflammatory effect of diclofenac.

KEY WORDSdiclofenac carrageenan edema anti-inflammatory  Download fulltext PDF



Autor: Sachin S. Sakat - Kamaraj Mani - Yulia O. Demidchenko - Evgeniy A. Gorbunov - Sergey A. Tarasov - Archna Mathur - Oleg 

Fuente: https://link.springer.com/







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