Faecal levels of calprotectin in systemic sclerosis are stable over time and are higher compared to primary Sjögren’s syndrome and rheumatoid arthritisReportar como inadecuado




Faecal levels of calprotectin in systemic sclerosis are stable over time and are higher compared to primary Sjögren’s syndrome and rheumatoid arthritis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Arthritis Research and Therapy

, 16:R46

First Online: 06 February 2014Received: 12 September 2013Accepted: 28 January 2014

Abstract

IntroductionFaecal calprotectin FC has been proposed to be a biomarker of gastrointestinal GI disease in systemic sclerosis SSc. The purpose of this study was to extend cross-sectional observations and prospectively assess the variability of FC over time in SSc patients. We also aimed to examine FC in relation to immunosuppressive therapy. Finally we wanted to analyse FC in other rheumatic diseases to evaluate the specificity of FC for SSc GI disease.

MethodsFC was measured in consecutive patients with SSc, primary Sjögren’s syndrome pSS, rheumatoid arthritis RA and in healthy hospital workers. The intraindividual variability of FC in SSc was assessed with intra class correlation ICC and κ statistics. Associations between FC and objective markers of GI disease and immunosuppressive medication were investigated.

ResultsFC was associated with micronutrient deficiency and GI pathology as assessed by cineradiography confirming our previous results. FC showed only a limited intra-individual variation in SSc, ICC = 0.69 95% confidence interval, CI: 0.57-0.78 and κ = 0.64 95% CI: 0.56-0.73. Generalised immunosuppression did not have any significant impact on FC. FC was significantly higher in SSc patients compared to patients with pSS or RA as well as compared to healthy subjects.

ConclusionsFC is a promising non-invasive biomarker for GI disease in SSc. In view of stable levels over time, FC could be a useful marker when novel, more specific drugs targeting the GI tract in SSc will be introduced.

AbbreviationsCIconfidence interval

CRPC-reactive protein

DAS28-CRP3Disease Activity Score 28 based on CRP and 3 variables

ELISAenzyme-linked immunosorbent assay

ESSDAIEULAR Disease Activity Index

FCfaecal calprotectin

GIgastrointestinal

IBDinflammatory bowel disease

ICCintra class correlation

IQRinterquartile range

PPIproton pump inhibitor

pSSprimary Sjögren’s syndrome

RArheumatoid arthritis

SScsystemic sclerosis

TNF-αtumor necrosis factor-alpha.

Electronic supplementary materialThe online version of this article doi:10.1186-ar4475 contains supplementary material, which is available to authorized users.

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Autor: Kristofer Andréasson - Tore Saxne - Agneta Scheja - Izabela Bartosik - Thomas Mandl - Roger Hesselstrand

Fuente: https://link.springer.com/







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