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Radiological Physics and Technology

, Volume 6, Issue 2, pp 343–348

First Online: 28 March 2013Received: 13 December 2012Revised: 07 March 2013Accepted: 10 March 2013


Diffusional kurtosis imaging DKI is a new technique based on non-Gaussian water diffusion analysis. However, the original DKI protocol six b values and 30 motion-probing gradient MPG directions requires more than 10 min of scanning time, which is too long for daily clinical use. We aimed to find suitable b value, MPG direction, and diffusion time settings for faster DKI. Four normal healthy subjects participated in the study. All DKI data sets were acquired on a clinical 3T-MRI scanner Philips Medical Systems with use of three protocols of 0–7500 s-mmb values, 6–32 MPG directions, and 23–80 ms diffusion time. There was a remarkable difference in the standard deviation SD of the mean DK values in the number of MPG directions. The mean DK values were significantly higher in the posterior limb of the internal capsule p = 0.003, r = 0.924 and thalamus p = 0.005, r = 0.903, whereas the mean DK values of the cerebrospinal fluid CSF p = 0.001, r = −0.976 were significantly lower when we used a longer diffusion time. Our results indicate that the SD of the mean DK values was higher in 15 MPG directions than in 20 MPG directions and more. Because the mean DK values of the CSF were significantly lower when we used longer diffusion times, we expect longer diffusion times to be useful for DKI. We propose the following imaging parameters for clinical use: 0, 1000, and 2000 s-mmb values; 20 MPG directions; Δ-δ 45.3-13.3 ms.

KeywordsMagnetic resonance imaging Diffusional kurtosis imaging Diffusion tensor imaging b value MPG direction Diffusion time  Download fulltext PDF

Autor: Issei Fukunaga - Masaaki Hori - Yoshitaka Masutani - Nozomi Hamasaki - Shuji Sato - Yuriko Suzuki - Fumitaka Kumagai - Masa

Fuente: https://link.springer.com/

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