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BMC Cardiovascular Disorders

, 13:56

Epidemiology

Abstract

BackgroundObesity causes severe healthcare problem worldwide leading to numerous diseases, such as cardiovascular diseases and diabetes mellitus. Previous Genome-Wide Association Study GWAS identified an association between a single nucleotide polymorphism SNP rs7138803, on chromosome 12q13 and obesity in European Caucasians. Since the genetic architecture governing the obesity may vary among different populations, we investigate the variant rs7138803 in Chinese population to find out whether it is associated with obesity.

MethodsA population-based cohort association study was carried out using the High Resolution Melt HRM method with 1851 participants. The association between rs7138803 genotypes and body mass index BMI was modeled with a general linear model, and a case–control study for the association between rs7138803 genotypes and obesity was performed using Pearson’s χ test. There was no indication of a deviation from Hardy-Weinberg equilibrium HWE p value = 0.51 in our sample.

ResultsNo association was detected between SNP rs7138803 and BMI in our Chinese Han population with a P value of 0.51. SNP rs7138803 was found to be not associated with common forms of obesity after adjusting for age and sex in the Chinese population. SNP rs7138803 was not associated with other obesity related traits, including T2DM, hypertension, lipid profiles, and ischemic stroke.

ConclusionOur data suggest that the rs7138803 exerts no significant effect on obesity in Chinese Han population. Larger cohorts may be more appropriate to detect an effect of this SNP on common obesity.

KeywordsFAIM2 Single nucleotide polymorphism Obesity susceptibility AbbreviationsGWASGenome-wide association study

HRMHigh resolution melt

HWEHardy-Weinberg equilibrium

BMIBody mass index

CADCoronary artery disease

TCTotal cholesterol

TGTriglyceride

HDL-CHigh-density lipoprotein cholesterol

LDL-CLow-density lipoprotein cholesterol

SNPSingle nucleotide polymorphism

T2DMType 2 diabetes mellitus

SBPSystolic blood pressure

DBPDiastolic blood pressure

AIAtherosclerosis index

PPPulse pressure.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-13-56 contains supplementary material, which is available to authorized users.

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Autor: Cong Li - Xueping Qiu - Na Yang - Jiajia Gao - Yuan Rong - Chenling Xiong - Fang Zheng

Fuente: https://link.springer.com/article/10.1186/1471-2261-13-56







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