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Cardiovascular Diabetology

, 13:67

First Online: 28 March 2014Received: 26 December 2013Accepted: 26 March 2014

Abstract

BackgroundWhereas visceral abdominal adipose tissue VAT is associated with cardiometabolic risk, there is debate regarding the role of subcutaneous abdominal adipose tissue SAT. The aim of this study was to investigate the relationships of subcutaneous and visceral abdominal fat with carotid atherosclerosis in patients with type 2 diabetes mellitus T2DM.

MethodsA total of 234 patients men 131, women 103, mean age: 53 years with T2DM were enrolled. Carotid intima-media thickness CIMT, abdominal subcutaneous fat thickness SFT and visceral fat thickness VFT were assessed by high-resolution B-mode ultrasonography US.

ResultsCompared to women, men had significantly higher VFT and lower SFT p = 0.002, p = 0.04, respectively. In partial correlation coefficient analyses between CIMT and abdominal fat thickness after adjustment for body mass index BMI, SFT showed a negative correlation with CIMT in men r = -0.27, p = 0.03. VFT was not correlated with CIMT in either men or women. In women, SFT was not correlated with CIMT r = -0.01, p = 0.93. VFT-SFT ratio was not correlated with CIMT in either men or women. In multivariate regression analyses adjusted for BMI and other CVD risk factors, SFT but not VFT was independently inversely associated with CIMT in men but not in women p < 0.001.

ConclusionsSFT assessed by US was inversely associated with carotid atherosclerosis in patients with T2DM, particularly men. Further research into the different roles of the two types of abdominal adipose tissue in both men and women is warranted.

KeywordsCarotid atherosclerosis Subcutaneous abdominal fat Subcutaneous fat thickness Visceral fat thickness Ultrasonography Type 2 diabetes mellitus AbbreviationsVATVisceral adipose tissue

SATSubcutaneous abdominal adipose tissue

T2DMType 2 diabetes mellitus

USUltrasonography

CIMTCarotid intima-media thickness

VFTVisceral fat thickness

SFTSubcutaneous fat thickness

MSMetabolic syndrome

CVDCardiovascular disease

CHDCoronary heart disease

CTComputed tomography

MRIMagnetic resonance imaging

HbA1cGlycated hemoglobin

TCTotal cholesterol

LDL-CLow density lipoprotein cholesterol

HDL-CHigh density lipoprotein cholesterol

TGTriglyceride

hs-CRPHigh-sensitivity C-reactive protein

HOMA-IRHomeostasis model assessment-insulin resistance

baPWVBrachial ankle pulse wave velocity

ABIAnkle brachial index

DNDiabetic nephropathy

BMIBody mass index

SDStandard deviation

SBPSystolic blood pressure

DBPDiastolic blood pressure

ACEIAngiotensin converting enzyme inhibitor

ARBAngiotensin receptor blocker.

Chan-Hee Jung, Bo-Yeon Kim contributed equally to this work.

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Autor: Chan-Hee Jung - Bo-Yeon Kim - Kyu-Jin Kim - Sang-Hee Jung - Chul-Hee Kim - Sung-Koo Kang - Ji-Oh Mok

Fuente: https://link.springer.com/article/10.1186/1475-2840-13-67



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