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Journal of Orthopaedics and Traumatology

, Volume 16, Issue 1, pp 35–39

First Online: 22 October 2014Received: 27 March 2014Accepted: 21 September 2014

Abstract

BackgroundVitamin D plays an important role in bone mineralization, remodeling, and maintenance and therefore its deficiency may be implicated in the pathogenesis of osteoarthritis OA. Vitamin D status was evaluated in patients with knee or hip OA scheduled for joint replacement. The impact of anthropometric parameters such as gender, age, and body mass index on vitamin D levels was also examined. The study was conducted in a Mediterranean country Greece.

Materials and methodsWe included 164 patients with knee or hip OA scheduled for joint replacement in this study. Serum levels of 25-hydroxyvitamin D vitamin D were measured in routine blood samples taken from the patients at their pre-admission visit, a week before the operation, using radioimmunoassay.

ResultsThe majority of patients were vitamin D deficient 81.7 %; 15.2 % of them were vitamin D insufficient hypovitaminosis. Only 3 % of patients were vitamin D sufficient. There was a significantly positive association between vitamin D levels and male gender.

ConclusionThese findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece. Many other possible predisposing factors for OA should be taken into consideration. Whether treatment with vitamin D supplements may provide beneficial effects to these patients and the stage of disease in which this treatment should commence remains an issue for further scientific investigation.

Level of evidenceLevel IV.

KeywordsVitamin D Osteoarthritis Knee osteoarthritis Hip osteoarthritis  Download fulltext PDF



Autor: Thomais Goula - Alexandros Kouskoukis - Georgios Drosos - Alexandros-Savvas Tselepis - Athanasios Ververidis - Christos Valk

Fuente: https://link.springer.com/







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